Inhibition of sialidase activity as a therapeutic approach
Identifieur interne : 000180 ( Main/Exploration ); précédent : 000179; suivant : 000181Inhibition of sialidase activity as a therapeutic approach
Auteurs : Victor Yu Glanz [Russie] ; Veronika A. Myasoedova ; Andrey V. Grechko [Russie] ; Alexander N. OrekhovSource :
- Drug Design, Development and Therapy [ 1177-8881 ] ; 2018.
Abstract
The demand for novel anti-influenza drugs persists, which is highlighted by the recent pandemics of influenza affecting thousands of people across the globe. One of the approaches to block the virus spreading is inhibiting viral sialidase (neuraminidase). This enzyme cleaves the sialic acid link between the newly formed virions and the host cell surface liberating the virions from the cell and maintaining the cycle of infection. Viral neuraminidases appear therefore as attractive therapeutic targets for preventing further spread of influenza infection. Compared to ion channel blockers that were the first approved anti-influenza drugs, neuraminidase inhibitors are well tolerated and target both influenza A and B viruses. Moreover, neuraminidase/sialidase inhibitors may be useful for managing some other human pathologies, such as cancer. In this review, we discuss the available knowledge on neuraminidase or sialidase inhibitors, their design, clinical application, and the current challenges.
Url:
DOI: 10.2147/DDDT.S176220
PubMed: 30349196
PubMed Central: 6186905
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of sialidase activity as a therapeutic approach</title><author><name sortKey="Glanz, Victor Yu" sort="Glanz, Victor Yu" uniqKey="Glanz V" first="Victor Yu" last="Glanz">Victor Yu Glanz</name><affiliation wicri:level="1"><nlm:aff id="af1-dddt-12-3431">Department of Genetics, Cytology and Bioengineering, Faculty of Biology and Medicine, Voronezh State University, Voronezh, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Genetics, Cytology and Bioengineering, Faculty of Biology and Medicine, Voronezh State University, Voronezh</wicri:regionArea><wicri:noRegion>Voronezh</wicri:noRegion></affiliation></author><author><name sortKey="Myasoedova, Veronika A" sort="Myasoedova, Veronika A" uniqKey="Myasoedova V" first="Veronika A" last="Myasoedova">Veronika A. Myasoedova</name><affiliation><nlm:aff id="af2-dddt-12-3431">Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia,<email>a.h.opexob@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Grechko, Andrey V" sort="Grechko, Andrey V" uniqKey="Grechko A" first="Andrey V" last="Grechko">Andrey V. Grechko</name><affiliation wicri:level="3"><nlm:aff id="af3-dddt-12-3431">Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Orekhov, Alexander N" sort="Orekhov, Alexander N" uniqKey="Orekhov A" first="Alexander N" last="Orekhov">Alexander N. 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Myasoedova</name><affiliation><nlm:aff id="af2-dddt-12-3431">Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia,<email>a.h.opexob@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Grechko, Andrey V" sort="Grechko, Andrey V" uniqKey="Grechko A" first="Andrey V" last="Grechko">Andrey V. Grechko</name><affiliation wicri:level="3"><nlm:aff id="af3-dddt-12-3431">Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Orekhov, Alexander N" sort="Orekhov, Alexander N" uniqKey="Orekhov A" first="Alexander N" last="Orekhov">Alexander N. Orekhov</name><affiliation><nlm:aff id="af2-dddt-12-3431">Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia,<email>a.h.opexob@gmail.com</email></nlm:aff></affiliation><affiliation><nlm:aff id="af4-dddt-12-3431">Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia,<email>a.h.opexob@gmail.com</email></nlm:aff></affiliation></author></analytic><series><title level="j">Drug Design, Development and Therapy</title><idno type="eISSN">1177-8881</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The demand for novel anti-influenza drugs persists, which is highlighted by the recent pandemics of influenza affecting thousands of people across the globe. One of the approaches to block the virus spreading is inhibiting viral sialidase (neuraminidase). This enzyme cleaves the sialic acid link between the newly formed virions and the host cell surface liberating the virions from the cell and maintaining the cycle of infection. Viral neuraminidases appear therefore as attractive therapeutic targets for preventing further spread of influenza infection. Compared to ion channel blockers that were the first approved anti-influenza drugs, neuraminidase inhibitors are well tolerated and target both influenza A and B viruses. Moreover, neuraminidase/sialidase inhibitors may be useful for managing some other human pathologies, such as cancer. 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Myasoedova</name><name sortKey="Orekhov, Alexander N" sort="Orekhov, Alexander N" uniqKey="Orekhov A" first="Alexander N" last="Orekhov">Alexander N. Orekhov</name></noCountry><country name="Russie"><noRegion><name sortKey="Glanz, Victor Yu" sort="Glanz, Victor Yu" uniqKey="Glanz V" first="Victor Yu" last="Glanz">Victor Yu Glanz</name></noRegion><name sortKey="Grechko, Andrey V" sort="Grechko, Andrey V" uniqKey="Grechko A" first="Andrey V" last="Grechko">Andrey V. Grechko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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